Buses run regularly from the twin border towns of Eagle Pass Texas and Piedras Negras Coahuila. Grupo Senda serves the area through its Coahuilenses buses, and ticket prices from the border are approximately $20. You can also bus in from the city of Monclova, about an hour away or other points in Coahuila and neighboring states.
Driving to Cuatro Cienegas is more practical, especially if you have a 4WD SUV or pickup. Some pozas and recreational areas are far off the main road. The protected area lies about 4 hours from the U.S. border.
